Pyrimidine-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANTXR1, B3GNT3, and C5orf24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANTXR1 grouped by Pyrimidine-containing compound biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANTXR1 →	-2.466	-0.165	.001	.002	3	5
STOMACH	B3GNT3 →	+3.860	+0.324	.001	.004	3	5
PANCREAS	C5orf24 →	-0.733	-0.235	.002	.008	3	4
BREAST	WASF1 →	-0.874	-0.209	.008	.005	2	5
BREAST	TSPAN1 →	+2.331	+0.208	.003	.006	3	4
STOMACH	ST14 →	+4.685	+0.366	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANTXR1 by Pyrimidine-containing compound biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →