Pyridine-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Pyridine-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, AKR1C1, and ACBD5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyridine-containing compound metabolic process activity versus GSR in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GSR →	+1.402	+0.275	.004	.002	3	6
LUNG_NSCLC_LUAD	AKR1C1 →	+4.091	+0.179	<.001	<.001	3	6
URINARY_TRACT	ACBD5 →	+1.017	+0.572	.003	.004	3	5
BLOOD_Myeloma	SLX1A →	+1.069	+0.147	.008	.002	3	5
UPPER_AERODIGESTIVE_TRACT	GPI →	+1.072	+0.322	.004	.004	2	6
UPPER_AERODIGESTIVE_TRACT	ATP5F1B →	+0.823	+0.258	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072524 vs GSR — STOMACH

Explore this scatter interactively →