Embryonic skeletal joint development

Across TCGA patient cohorts, RNA activity of the Embryonic skeletal joint development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1E2, MAGOH2P, and SHISA5P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic skeletal joint development activity versus ATP6V1E2 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATP6V1E2 →	+0.457	+0.161	<.001	.002	3	4
PDAC	MAGOH2P →	+0.424	+0.159	.001	.003	3	4
OV	SHISA5P2 →	+1.031	+0.138	.001	.002	3	3
PDAC	TFDP2 →	+0.388	+0.208	<.001	<.001	3	3
PDAC	LANCL2 →	+0.305	+0.183	<.001	<.001	3	3
PDAC	FRG1BP →	+0.389	+0.151	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072498 vs ATP6V1E2 — BRCA

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