Embryonic skeletal joint development

Across TCGA pan-cancer cohorts, RNA activity of the Embryonic skeletal joint development pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Embryonic skeletal joint development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and UVM, show the opposite pattern, with higher activity associated with better survival.

UCS, UVM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.587	0.132	<.001	68	view →
UVM	DFS	Tertile	All	0.894	0.496	.001	52	view →
LGG	DFS	Median	All	0.464	0.319	<.001	51	view →
LUSC	OS	Tertile	II,III,IV	0.838	0.678	.004	32	view →
KICH	OS	Median	II,III,IV	0.520	1.000	.008	24	view →
ESCA	DFS	Quartile	II,III,IV	0.122	1.000	.006	23	view →
LIHC	OS	Median	II,III,IV	0.827	0.593	.003	22	view →
CHOL	DFS	Quartile	II,III,IV	0.151	0.685	.022	21	view →
LUAD	DFS	Tertile	III,IV	0.511	0.685	.028	20	view →
COAD	OS	Tertile	II,III,IV	0.967	0.805	.011	19	view →
UCEC	DFS	Quartile	All	0.926	0.860	.012	18	view →
KIRP	DFS	Quartile	All	0.472	1.000	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0072498–UCS (DFS)

Open the UCS breakdown →