Response to cell cycle checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Response to cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS23P2, KDELR3, and VWA5A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cell cycle checkpoint signaling activity versus RPS23P2 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS23P2 →	-0.093	-0.348	.007	.005	3	3
LSCC	KDELR3 →	-0.389	-0.343	.001	.001	3	3
GBM	VWA5A →	-0.530	-0.231	<.001	<.001	3	3
PDAC	THADA →	-0.198	-0.705	.001	.002	3	3
PDAC	MRPL44 →	-0.158	-0.582	.007	.002	3	3
PDAC	TMEM47 →	-0.558	-0.633	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072396 vs RPS23P2 — LUAD

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