Response to cell cycle checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Response to cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSWIM9, OTUD5, and EIF2S3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSWIM9 grouped by Response to cell cycle checkpoint signaling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZSWIM9 →	-0.431	-0.599	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	OTUD5 →	-0.826	-0.267	.001	.006	3	4
BONE	EIF2S3 →	-1.010	-1.347	.003	.009	3	4
CNS	BRF2 →	-0.560	-0.590	<.001	.003	3	3
CNS	PPP5D1 →	-0.375	-0.492	<.001	.007	3	3
LUNG_NSCLC_LUAD	JADE3 →	-0.503	-0.451	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSWIM9 by Response to cell cycle checkpoint signaling activity — CNS

Explore this box plot interactively →