Plus-end-directed organelle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Plus-end-directed organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXM1, CDC20, and SKA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plus-end-directed organelle transport along microtubule activity versus FOXM1 in BRCA (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXM1 →	-0.763	-0.277	<.001	<.001	3	5
BRCA	CDC20 →	-1.411	-0.404	<.001	<.001	3	5
BRCA	SKA3 →	-0.757	-0.413	.001	.001	3	5
UCEC	BLM →	-0.531	-0.205	.005	.004	3	5
BRCA	CENPW →	-1.006	-0.440	<.001	<.001	3	5
BRCA	NCAPG →	-0.895	-0.434	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072386 vs FOXM1 — BRCA

Explore this scatter interactively →