Sulfur compound transport

Across TCGA patient cohorts, RNA activity of the Sulfur compound transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GCHFR, CES1, and MAP1B_S1016, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound transport activity versus GCHFR in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GCHFR →	+0.638	+0.030	<.001	.007	3	5
GBM	CES1 →	+0.642	+0.033	<.001	<.001	3	5
UCEC	MAP1B_S1016 →	+0.673	+0.045	.003	.002	3	4
GBM	CTSZ →	+0.494	+0.036	<.001	<.001	3	4
PDAC	CYP27A1 →	+0.333	+0.029	<.001	<.001	3	4
LUAD	ELMO2 →	+0.149	+0.027	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072348 vs GCHFR — GBM

Explore this scatter interactively →