Rescue of stalled ribosome

Across TCGA cell cohorts, RNA activity of the Rescue of stalled ribosome pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITFG1, CA13, and GAPDH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITFG1 grouped by Rescue of stalled ribosome-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITFG1 →	+1.045	+0.205	<.001	.001	3	4
PANCREAS	CA13 →	+1.390	+0.188	<.001	<.001	3	4
LIVER	GAPDH →	-1.015	-0.249	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MED12 →	-0.844	-0.161	.003	.002	3	4
LUNG_NSCLC_LUAD	TNFRSF1A →	-1.009	-0.142	.001	.004	3	4
LUNG_SCLC	WASHC5 →	+0.752	+0.199	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITFG1 by Rescue of stalled ribosome activity — LUNG_SCLC

Explore this box plot interactively →