Rescue of stalled ribosome

Across TCGA cell cohorts, RNA activity of the Rescue of stalled ribosome pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM44, DCTN5, and NDUFAF4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rescue of stalled ribosome activity versus TIMM44 in BONE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TIMM44 →	+1.452	+0.313	.001	.001	3	6
CNS	DCTN5 →	+0.523	+0.147	<.001	.002	3	6
LUNG_SCLC	NDUFAF4 →	+0.883	+0.178	.005	.004	2	6
PANCREAS	MDN1 →	+0.924	+0.201	.001	<.001	3	5
BONE	SAFB2 →	+0.798	+0.274	.001	.002	3	5
PANCREAS	POLR3B →	+0.935	+0.249	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072344 vs TIMM44 — BONE

Explore this scatter interactively →