Modified amino acid transport

Across TCGA patient cohorts, RNA activity of the Modified amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3D, TMSB15B-AS1, and ELF2P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modified amino acid transport activity versus APOBEC3D in HNSC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	APOBEC3D →	-0.423	-0.445	.007	.009	3	5
CCRCC	TMSB15B-AS1 →	-0.374	-0.535	<.001	.001	3	5
CCRCC	ELF2P1 →	-0.341	-0.520	.003	.002	3	5
BRCA	BTN3A3 →	-0.624	-0.395	<.001	.005	3	4
BRCA	RSU1 →	-0.687	-0.673	.001	<.001	3	4
BRCA	PLCL2 →	-0.485	-0.376	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072337 vs APOBEC3D — HNSC

Explore this scatter interactively →