Intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCN12, TRIM53AP, and NME8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LCN12 grouped by Intrinsic apoptotic signaling pathway by p53 class mediator-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LCN12 →	-0.254	-0.067	.007	.006	3	4
OVARY	TRIM53AP →	-0.286	-0.094	.006	.009	2	5
OVARY	NME8 →	-0.243	-0.072	.009	.009	2	5
LARGE_INTESTINE	EIF4E →	-0.421	-0.057	<.001	.005	3	4
PANCREAS	CEACAM21 →	+0.162	+0.074	<.001	<.001	3	4
SOFT_TISSUE	ACLY →	-0.318	-0.086	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LCN12 by Intrinsic apoptotic signaling pathway by p53 class mediator activity — OVARY

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