Signal transduction by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Signal transduction by p53 class mediator pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and LIG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction by p53 class mediator activity versus SMC2 in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.775	+0.035	<.001	<.001	3	7
LUAD	SMC4 →	+0.528	+0.035	<.001	<.001	3	7
LUAD	LIG1 →	+0.406	+0.028	<.001	<.001	3	7
LUAD	MSH6 →	+0.445	+0.032	<.001	<.001	3	7
LUAD	BOD1L1_S1531 →	+0.557	+0.034	<.001	<.001	3	7
HNSC	RFC2 →	+0.367	+0.059	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072331 vs SMC2 — GBM

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