Signal transduction by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEMIP, ZNF181, and XKR4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction by p53 class mediator activity versus CEMIP in COAD (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEMIP →	+0.964	+0.160	.002	.001	3	2
COAD	ZNF181 →	-0.486	-0.176	<.001	<.001	3	2
OV	XKR4 →	-1.554	-0.177	.001	.002	3	2
OV	CYCSP39 →	+0.872	+0.160	.009	.003	3	2
BRCA	MYZAP →	-1.753	-0.273	.003	.002	3	2
COAD	FTSJ3 →	+0.442	+0.149	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072331 vs CEMIP — COAD

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