Monocarboxylic acid catabolic process

Across TCGA patient cohorts, RNA activity of the Monocarboxylic acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHYH, LDHD, and ALDH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid catabolic process activity versus PHYH in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PHYH →	+0.481	+0.049	<.001	.006	3	7
OV	LDHD →	+0.528	+0.032	.005	.001	3	6
COAD	ALDH2 →	+0.620	+0.022	<.001	<.001	3	6
BRCA	NFIA →	+0.566	+0.026	<.001	<.001	3	6
LSCC	TOM1L1 →	+0.282	+0.026	.004	.004	3	6
LUAD	CKAP4_S26 →	-0.470	-0.028	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072329 vs PHYH — HNSC

Explore this scatter interactively →