Monocarboxylic acid catabolic process

Across TCGA patient cohorts, RNA activity of the Monocarboxylic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPL, TEDC2, and H2AZ1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid catabolic process activity versus CENPL in COAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPL →	-0.492	-0.124	<.001	.004	3	6
LSCC	TEDC2 →	-0.582	-0.172	.001	.003	3	6
COAD	H2AZ1 →	-0.758	-0.165	<.001	<.001	3	6
LUAD	FANCE →	-0.263	-0.165	.008	<.001	3	6
GBM	LMNB1 →	-0.732	-0.178	<.001	<.001	3	5
COAD	ECT2 →	-0.711	-0.155	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072329 vs CENPL — COAD

Explore this scatter interactively →