Vesicle uncoating

Across TCGA cell cohorts, RNA activity of the Vesicle uncoating pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC24A1, PEA15, and SRPRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC24A1 grouped by Vesicle uncoating-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC24A1 →	-1.081	-0.456	.007	.002	3	5
LIVER	PEA15 →	-1.478	-0.279	.001	.008	3	5
SKIN	SRPRB →	+0.699	+0.240	<.001	<.001	3	4
SOFT_TISSUE	NFATC3 →	+0.531	+0.377	.009	<.001	3	4
CNS	ADCK5 →	+0.623	+0.243	.002	.003	3	4
BREAST	DTX4 →	+1.625	+0.198	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC24A1 by Vesicle uncoating activity — SOFT_TISSUE

Explore this box plot interactively →