Vesicle uncoating

Across TCGA cell cohorts, RNA activity of the Vesicle uncoating pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UQCR11, TANGO6, and SH3GL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle uncoating activity versus UQCR11 in OVARY (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UQCR11 →	+0.667	+0.167	.001	.004	3	5
LUNG_SCLC	TANGO6 →	+0.824	+0.164	<.001	.001	3	5
LUNG_SCLC	SH3GL1 →	+0.602	+0.162	.004	.003	3	5
BREAST	HSD17B1 →	+2.149	+0.178	.006	<.001	3	5
BREAST	DHRS4L2 →	+0.915	+0.201	.004	<.001	3	5
LUNG_NSCLC_LUAD	CLTB →	+0.757	+0.129	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072319 vs UQCR11 — OVARY

Explore this scatter interactively →