Metanephric nephron morphogenesis

Across TCGA cell cohorts, RNA activity of the Metanephric nephron morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRB1, C1orf54, and RCBTB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARRB1 grouped by Metanephric nephron morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARRB1 →	-1.793	-1.024	<.001	.001	3	4
PANCREAS	C1orf54 →	+0.494	+0.743	.005	.009	3	4
UPPER_AERODIGESTIVE_TRACT	RCBTB1 →	-0.695	-0.641	.001	.008	3	3
CNS	MYO1E →	+1.339	+1.026	.001	.001	3	3
LIVER	SCYL1 →	+0.416	+1.315	<.001	.001	3	3
URINARY_TRACT	UST →	-1.734	-1.445	.004	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARRB1 by Metanephric nephron morphogenesis activity — CNS

Explore this box plot interactively →