Metanephric proximal tubule development

Across TCGA patient cohorts, RNA activity of the Metanephric proximal tubule development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM172A, KPNA2, and PTPN2_S304, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric proximal tubule development activity versus FAM172A in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM172A →	+0.220	+0.048	.002	<.001	3	5
BRCA	KPNA2 →	-0.584	-0.055	<.001	.002	3	5
UCEC	PTPN2_S304 →	-0.503	-0.054	.003	.004	3	4
COAD	SCARF2 →	+0.625	+0.053	<.001	<.001	3	4
COAD	SMARCC1 →	-0.226	-0.054	<.001	.002	3	4
BRCA	TNS2 →	+0.355	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072237 vs FAM172A — BRCA

Explore this scatter interactively →