Metanephric proximal tubule development

Across TCGA pan-cancer cohorts, RNA activity of the Metanephric proximal tubule development pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Metanephric proximal tubule development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and KIRC, show the opposite pattern, with higher activity associated with better survival.

LIHC, BLCA, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.624	0.416	<.001	89	view →
BLCA	DFS	Median	All	0.239	0.436	<.001	66	view →
UVM	DFS	Median	All	0.409	0.731	<.001	57	view →
KIRC	DFS	Quartile	All	0.703	0.517	<.001	54	view →
LGG	DFS	Median	All	0.575	0.847	<.001	54	view →
PAAD	OS	Quartile	All	0.661	0.261	<.001	48	view →
THCA	OS	Tertile	All	0.755	1.000	.001	45	view →
UCEC	DFS	Tertile	IV	0.376	0.788	.002	44	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.519	.004	40	view →
OV	OS	Tertile	III,IV	0.218	0.360	<.001	38	view →
HNSC	DFS	Median	III,IV	0.678	0.519	.003	30	view →
LAML	DFS	Median	All	0.670	0.457	.013	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0072237–LIHC (OS)

Open the LIHC breakdown →