Metanephric loop of Henle development

Across TCGA patient cohorts, RNA activity of the Metanephric loop of Henle development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLSTN1, GPC1, and SDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric loop of Henle development activity versus CLSTN1 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLSTN1 →	+0.565	+0.090	<.001	<.001	3	5
LSCC	GPC1 →	+0.811	+0.100	<.001	<.001	3	5
BRCA	SDC1 →	+0.698	+0.065	<.001	<.001	3	4
CCRCC	TMF1 →	-0.217	-0.085	.004	.001	3	4
GBM	EGFR →	+0.871	+0.074	.001	<.001	3	4
HNSC	FKBP14 →	+0.404	+0.087	.002	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072236 vs CLSTN1 — LSCC

Explore this scatter interactively →