Metanephric loop of Henle development

Across TCGA cell cohorts, RNA activity of the Metanephric loop of Henle development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKD2, MAPK8IP3, and PKD1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric loop of Henle development activity versus PKD2 in BONE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PKD2 →	+1.717	+0.535	<.001	.009	3	15
OESOPHAGUS	MAPK8IP3 →	+1.629	+0.146	.004	.007	2	12
LARGE_INTESTINE	PKD1 →	+1.719	+0.804	<.001	<.001	3	11
SOFT_TISSUE	DNAJB14 →	+0.712	+0.195	<.001	<.001	2	12
SKIN	TRIOBP →	+1.567	+0.354	<.001	<.001	3	11
BLOOD_Leukemia	FKRP →	+0.747	+0.189	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072236 vs PKD2 — BONE

Explore this scatter interactively →