Metanephric glomerulus development

Across TCGA cell cohorts, RNA activity of the Metanephric glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5orf22, PRPF38A, and APOOL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C5orf22 grouped by Metanephric glomerulus development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C5orf22 →	-0.701	-0.737	.001	.001	3	4
LUNG_SCLC	PRPF38A →	-0.526	-0.609	.003	.007	3	3
URINARY_TRACT	APOOL →	-1.433	-2.054	.006	<.001	3	3
LUNG_SCLC	TMSB15B →	-2.815	-0.950	<.001	.003	3	3
LUNG_SCLC	GPAT4 →	-1.068	-0.713	<.001	.001	3	3
LUNG_SCLC	OTUD3 →	-1.056	-0.761	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C5orf22 by Metanephric glomerulus development activity — OVARY

Explore this box plot interactively →