Metanephric epithelium development

Across TCGA patient cohorts, RNA activity of the Metanephric epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99, C8orf88, and CLDN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric epithelium development activity versus CD99 in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD99 →	+0.592	+0.421	.009	.002	3	5
COAD	C8orf88 →	+0.562	+0.097	.001	.001	3	4
UCEC	CLDN5 →	+0.696	+0.127	.003	.003	3	4
BRCA	LAYN →	+0.534	+0.399	.007	.001	3	4
PDAC	ADAMTS2 →	+0.446	+0.160	.008	.003	3	4
LUAD	AQP8 →	+0.094	+0.204	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072207 vs CD99 — BRCA

Explore this scatter interactively →