Metanephric epithelium development

Across TCGA pan-cancer cohorts, RNA activity of the Metanephric epithelium development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher Metanephric epithelium development pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and ACC, show the opposite pattern, with higher activity associated with better survival.

ESCA, BLCA, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Quartile	II,III,IV	0.929	0.616	<.001	87	view →
BLCA	OS	Median	III,IV	0.285	0.575	<.001	35	view →
SCLC	OS	Quartile	II,III,IV	0.253	0.621	.005	31	view →
PAAD	OS	Median	All	0.530	0.690	.003	20	view →
THYM	OS	Median	All	0.722	0.970	.002	19	view →
UVM	DFS	Quartile	All	0.210	0.887	.008	18	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	15	view →
ACC	OS	Median	II,III,IV	0.777	0.439	.008	13	view →
LUAD	DFS	Quartile	All	0.355	0.569	.006	10	view →
LIHC	OS	Quartile	All	0.638	0.477	.015	10	view →
COAD	DFS	Tertile	All	0.729	0.823	.012	9	view →
DLBC	OS	Tertile	III,IV	0.209	0.797	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0072207–ESCA (OS)

Open the ESCA breakdown →