Metanephric epithelium development

Across TCGA cell cohorts, RNA activity of the Metanephric epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED8, ALG1, and ALDH6A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED8 grouped by Metanephric epithelium development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMED8 →	-1.313	-1.480	<.001	<.001	3	5
LUNG_SCLC	ALG1 →	+1.208	+1.296	<.001	.005	3	5
LUNG_SCLC	ALDH6A1 →	-0.885	-1.058	.001	<.001	3	4
LUNG_SCLC	TMEM181 →	-1.295	-1.152	<.001	.007	3	4
URINARY_TRACT	WDR27 →	-1.309	-1.544	.006	<.001	3	4
LARGE_INTESTINE	S100PBP →	-0.623	-0.954	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED8 by Metanephric epithelium development activity — LUNG_SCLC

Explore this box plot interactively →