Cell proliferation involved in metanephros development

Across TCGA patient cohorts, RNA activity of the Cell proliferation involved in metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF114, IER2, and MIR601, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell proliferation involved in metanephros development activity versus RNF114 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNF114 →	+0.282	+0.655	<.001	.001	3	3
PDAC	IER2 →	+0.320	+0.688	.009	.004	3	3
COAD	MIR601 →	+0.982	+0.344	<.001	.004	3	3
LUAD	STRA6LP →	-0.036	-0.592	<.001	.002	3	3
GBM	CCDC80 →	+0.892	+0.871	<.001	<.001	3	3
PDAC	GABRE →	+0.636	+0.726	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072203 vs RNF114 — GBM

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