Cell proliferation involved in metanephros development

Across TCGA cell cohorts, RNA activity of the Cell proliferation involved in metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR1, DSE, and LOXL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPAR1 grouped by Cell proliferation involved in metanephros development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LPAR1 →	-3.494	-1.502	.005	.001	3	4
CNS	DSE →	-1.176	-1.074	<.001	<.001	3	3
CNS	LOXL1 →	-2.412	-1.067	<.001	<.001	3	3
CNS	ANKRD16 →	+0.552	+1.127	.004	.001	3	3
CNS	ZNF23 →	-0.617	-1.098	<.001	<.001	3	3
SOFT_TISSUE	TRABD →	+0.681	+1.104	.006	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPAR1 by Cell proliferation involved in metanephros development activity — SOFT_TISSUE

Explore this box plot interactively →