Nephric duct morphogenesis

Across TCGA cell cohorts, RNA activity of the Nephric duct morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RABEP1, STK17A, and SLC37A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RABEP1 grouped by Nephric duct morphogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RABEP1 →	+0.529	+0.570	.003	.006	3	4
CNS	STK17A →	+1.506	+0.979	.002	.002	3	4
BREAST	SLC37A3 →	-0.714	-0.737	.003	.003	3	3
BONE	GATA3 →	-1.155	-1.434	.006	.001	3	3
BONE	HASPIN →	-0.623	-1.368	.007	.003	3	3
KIDNEY	ACY1 →	-0.865	-0.866	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RABEP1 by Nephric duct morphogenesis activity — PANCREAS

Explore this box plot interactively →