Mesonephric duct development

Across TCGA patient cohorts, RNA activity of the Mesonephric duct development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB27A, CYBA, and CYBB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric duct development activity versus RAB27A in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAB27A →	-0.369	-0.071	<.001	<.001	3	6
BRCA	CYBA →	-0.459	-0.046	.001	.008	3	6
LSCC	CYBB →	-0.763	-0.112	<.001	<.001	3	6
LSCC	HLA-F →	-0.513	-0.074	<.001	<.001	3	6
LSCC	RHBDF2_S385 →	-0.571	-0.087	<.001	.002	3	5
GBM	SAMSN1_S107 →	-0.553	-0.089	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072177 vs RAB27A — LSCC

Explore this scatter interactively →