Mesonephric duct development

Across TCGA patient cohorts, RNA activity of the Mesonephric duct development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF2, SMIM6, and TRMT2B-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephric duct development activity versus NCF2 in LUAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCF2 →	-0.461	-0.290	.004	.008	3	4
LUAD	SMIM6 →	+0.509	+0.311	<.001	<.001	3	4
LSCC	TRMT2B-AS1 →	+0.694	+0.353	<.001	<.001	3	3
BRCA	DLX4 →	+0.830	+0.381	<.001	.001	3	3
CCRCC	TSFM →	+0.254	+0.477	.005	.005	3	3
LSCC	SLC16A3 →	-0.410	-0.214	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072177 vs NCF2 — LUAD

Explore this scatter interactively →