Mesonephric duct development

Across TCGA cell cohorts, RNA activity of the Mesonephric duct development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPC3, WNT11, and MYOG, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPC3 grouped by Mesonephric duct development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GPC3 →	-0.381	-1.275	.002	<.001	3	13
STOMACH	WNT11 →	-0.228	-1.113	<.001	.002	3	8
SKIN	MYOG →	-0.135	-0.960	.003	.007	3	5
LARGE_INTESTINE	HNF1B →	-0.320	-1.308	<.001	<.001	3	5
PANCREAS	WNT9B →	-0.146	-0.840	.005	.003	2	6
LUNG_NSCLC_LUAD	PAFAH1B3 →	-0.186	-1.263	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPC3 by Mesonephric duct development activity — BREAST

Explore this box plot interactively →