Nephric duct development

Across TCGA patient cohorts, RNA activity of the Nephric duct development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAL1, TRBJ2-6, and ANP32AP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephric duct development activity versus DNAL1 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DNAL1 →	+0.462	+0.194	<.001	.002	3	5
HNSC	TRBJ2-6 →	-0.981	-0.291	<.001	<.001	3	5
GBM	ANP32AP1 →	+0.365	+0.445	.001	.004	3	4
PDAC	ARL11 →	-0.216	-0.220	.008	.004	3	4
HNSC	S100A9 →	-1.622	-0.264	<.001	.003	3	4
HNSC	CORO1A →	-0.662	-0.168	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072176 vs DNAL1 — HNSC

Explore this scatter interactively →