Epithelial tube formation

Across TCGA patient cohorts, RNA activity of the Epithelial tube formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, RCOR3, and PFN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial tube formation activity versus FSTL1 in LSCC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FSTL1 →	+0.588	+0.039	<.001	<.001	3	6
HNSC	RCOR3 →	+0.290	+0.038	<.001	<.001	3	6
HNSC	PFN2 →	+0.496	+0.052	.001	<.001	3	6
COAD	MACROH2A2 →	+0.286	+0.014	.008	.006	2	7
LUAD	TP53BP1_S660 →	+0.458	+0.021	.006	.009	3	5
LSCC	GIMAP4_S58 →	-0.623	-0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072175 vs FSTL1 — LSCC

Explore this scatter interactively →