Epithelial tube formation

Across TCGA patient cohorts, RNA activity of the Epithelial tube formation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGNL1, CEP152, and SFR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial tube formation activity versus CGNL1 in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CGNL1 →	+0.468	+0.442	.001	.002	3	3
PDAC	CEP152 →	-0.334	-1.119	.002	<.001	3	2
PDAC	SFR1 →	-0.492	-1.067	.003	<.001	3	2
PDAC	RPS29P3 →	+0.359	+0.682	.001	.003	3	2
PDAC	RPL21P23 →	-0.365	-0.693	.006	<.001	3	2
PDAC	LINC02626 →	-0.429	-1.065	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072175 vs CGNL1 — COAD

Explore this scatter interactively →