Epithelial tube formation

Across TCGA cell cohorts, RNA activity of the Epithelial tube formation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TET1, MAN2A2, and C12orf73, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial tube formation activity versus TET1 in LIVER (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TET1 →	-1.570	-0.444	.005	.004	3	5
LIVER	MAN2A2 →	-1.311	-0.300	.001	.002	3	5
OVARY	C12orf73 →	-0.604	-0.211	<.001	<.001	3	5
BLOOD_Leukemia	E2F2 →	-1.758	-0.178	<.001	<.001	3	5
LARGE_INTESTINE	TRIB2 →	+2.045	+0.266	<.001	<.001	3	5
LIVER	UGCG →	+2.158	+0.269	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072175 vs TET1 — LIVER

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