Metanephric tubule formation

Across TCGA patient cohorts, RNA activity of the Metanephric tubule formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, RCSD1, and ITGA1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric tubule formation activity versus SOX9 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOX9 →	+1.033	+0.339	<.001	.002	3	9
COAD	RCSD1 →	-0.378	-0.066	.002	.001	3	5
GBM	ITGA1 →	-0.380	-0.135	.001	.002	3	5
COAD	MYLK_S1852 →	-0.719	-0.054	.003	.009	3	5
BRCA	WDR12 →	+0.203	+0.083	.007	<.001	3	5
GBM	CD34 →	-0.632	-0.128	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072174 vs SOX9 — LSCC

Explore this scatter interactively →