Metanephric mesenchymal cell differentiation

Across TCGA cell cohorts, RNA activity of the Metanephric mesenchymal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, RAB31, and ZNF250, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIMELESS grouped by Metanephric mesenchymal cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TIMELESS →	-1.259	-2.128	.007	<.001	3	5
BLOOD_Leukemia	RAB31 →	+2.265	+0.800	.001	.005	3	5
BLOOD_Leukemia	ZNF250 →	-0.585	-0.671	<.001	.007	3	5
BLOOD_Leukemia	TIGD3 →	-0.672	-0.899	<.001	.001	3	4
BLOOD_Leukemia	SHF →	-1.336	-1.043	.006	.002	3	4
BLOOD_Leukemia	FAIM →	-2.063	-0.713	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIMELESS by Metanephric mesenchymal cell differentiation activity — BONE

Explore this box plot interactively →