Mesenchymal cell differentiation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell differentiation involved in kidney development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB1I1, FERMT2, and RAI14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell differentiation involved in kidney development activity versus TGFB1I1 in CCRCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TGFB1I1 →	-0.438	-0.069	.002	.002	3	6
CCRCC	FERMT2 →	-0.376	-0.087	<.001	<.001	3	6
UCEC	RAI14 →	-0.348	-0.107	.002	<.001	3	6
LSCC	PDLIM7 →	-0.468	-0.075	.001	.002	3	6
CCRCC	PEAK1 →	-0.298	-0.071	<.001	.001	3	6
UCEC	ZYX_S267 →	-0.485	-0.099	.002	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072161 vs TGFB1I1 — CCRCC

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