Mesenchymal cell differentiation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell differentiation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPCA, TNIP1, and ZNF107, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HPCA grouped by Mesenchymal cell differentiation involved in kidney development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HPCA →	-0.970	-1.200	.009	.004	2	6
OESOPHAGUS	TNIP1 →	+1.147	+1.211	.004	<.001	3	4
LUNG_SCLC	ZNF107 →	-1.076	-1.250	<.001	.005	3	4
BLOOD_Leukemia	CXorf38 →	+0.837	+1.021	<.001	.003	3	4
LUNG_NSCLC_LUAD	ING5 →	-0.528	-0.749	.003	.001	3	4
STOMACH	NUAK1 →	+1.680	+1.126	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HPCA by Mesenchymal cell differentiation involved in kidney development activity — SOFT_TISSUE

Explore this box plot interactively →