Mesangial cell development

Across TCGA patient cohorts, RNA activity of the Mesangial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCK2, PRKG1, and RSU1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesangial cell development activity versus NCK2 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NCK2 →	+0.223	+0.084	.001	<.001	3	6
CCRCC	PRKG1 →	+0.452	+0.069	.002	.004	3	6
BRCA	RSU1 →	+0.405	+0.058	<.001	<.001	3	5
CCRCC	TGFB1I1 →	+0.460	+0.066	.003	.008	3	5
BRCA	CDC42EP1_S353 →	+0.495	+0.051	.004	<.001	3	5
OV	CNRIP1 →	+0.622	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072143 vs NCK2 — CCRCC

Explore this scatter interactively →