Mesangial cell development

Across TCGA patient cohorts, RNA activity of the Mesangial cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT27, PGM5, and GYPC, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesangial cell development activity versus IFT27 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IFT27 →	+0.447	+0.475	<.001	.007	3	3
LUAD	PGM5 →	+0.736	+0.476	.003	.007	3	3
BRCA	GYPC →	+0.620	+0.417	.002	.007	3	3
BRCA	GPR176 →	+0.535	+0.383	<.001	.004	3	3
BRCA	PARPBP →	-0.660	-0.457	<.001	.002	3	3
PDAC	ADCY2 →	+0.263	+0.150	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072143 vs IFT27 — LUAD

Explore this scatter interactively →