Mesangial cell development

Across TCGA cell cohorts, RNA activity of the Mesangial cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10RA, CCDC116, and ZNF233, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL10RA grouped by Mesangial cell development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IL10RA →	+0.187	+0.884	<.001	.001	3	4
SOFT_TISSUE	CCDC116 →	+0.412	+0.212	.007	.001	3	4
BONE	ZNF233 →	-0.214	-1.078	.003	.008	3	4
OVARY	BRF2 →	+0.174	+0.833	<.001	.001	3	4
LUNG_SCLC	LGMN →	+0.143	+0.870	.004	.008	3	4
LUNG_NSCLC_LUAD	IRAK4 →	-0.108	-0.794	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL10RA by Mesangial cell development activity — OVARY

Explore this box plot interactively →