Mesenchyme morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesenchyme morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYGB, TNN, and TBX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchyme morphogenesis activity versus CYGB in CCRCC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CYGB →	+0.885	+0.327	<.001	<.001	3	7
CCRCC	TNN →	+0.526	+0.241	<.001	<.001	3	6
CCRCC	TBX2 →	+0.941	+0.331	<.001	<.001	3	6
UCEC	TBX3 →	+0.987	+0.252	<.001	<.001	3	6
BRCA	HMCN1 →	+0.947	+0.310	<.001	<.001	3	6
BRCA	ZEB1 →	+0.766	+0.355	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072132 vs CYGB — CCRCC

Explore this scatter interactively →