Cell proliferation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Cell proliferation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXA3, LRRCC1, and C1GALT1C1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOXA3 grouped by Cell proliferation involved in kidney development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HOXA3 →	-1.670	-1.025	.001	.005	3	4
LUNG_NSCLC_LUSC	LRRCC1 →	-1.006	-1.188	.004	.003	3	4
URINARY_TRACT	C1GALT1C1 →	-1.246	-2.176	.002	<.001	3	4
LUNG_SCLC	SHBG →	-0.716	-1.061	.005	.003	3	3
LUNG_SCLC	SLC35D2 →	-2.920	-1.568	<.001	<.001	3	3
LUNG_SCLC	INCA1 →	-0.748	-1.200	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOXA3 by Cell proliferation involved in kidney development activity — LUNG_SCLC

Explore this box plot interactively →