Glomerulus morphogenesis

Across TCGA patient cohorts, RNA activity of the Glomerulus morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, LAMA4, and PRKG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerulus morphogenesis activity versus CNRIP1 in BRCA (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+0.674	+0.096	<.001	<.001	3	8
OV	LAMA4 →	+0.613	+0.096	<.001	<.001	3	8
OV	PRKG1 →	+0.769	+0.078	<.001	<.001	3	8
OV	RFC4 →	-0.393	-0.065	<.001	.003	3	8
BRCA	TLN2 →	+0.608	+0.100	<.001	<.001	3	8
BRCA	RAI14 →	+0.440	+0.090	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072102 vs CNRIP1 — BRCA

Explore this scatter interactively →