Stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NES, TWF1, and CORO1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stem cell proliferation activity versus NES in CNS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NES →	+3.062	+1.189	.005	.002	3	6
URINARY_TRACT	TWF1 →	-0.837	-1.156	.006	.006	3	5
STOMACH	CORO1C →	-1.597	-1.189	.006	.001	3	4
STOMACH	C10orf95 →	+0.858	+1.300	<.001	<.001	3	4
SOFT_TISSUE	PTPRJ →	-2.087	-1.846	<.001	<.001	3	4
SOFT_TISSUE	PTPN11 →	-0.695	-1.684	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072089 vs NES — CNS

Explore this scatter interactively →