Kidney mesenchyme development

Across TCGA patient cohorts, RNA activity of the Kidney mesenchyme development pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMER1, NFAT5, and SOS1, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney mesenchyme development activity versus AMER1 in KICH (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	AMER1 →	+0.954	+0.062	<.001	<.001	3	25
THYM	NFAT5 →	+1.085	+0.054	<.001	<.001	3	22
UCS	SOS1 →	+0.564	+0.079	.001	<.001	3	22
THYM	REV1 →	+0.821	+0.057	<.001	<.001	2	23
KICH	ERCC6L2 →	+1.028	+0.059	<.001	.001	3	22
DLBC	CEP290 →	+0.943	+0.072	<.001	.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072074 vs AMER1 — KICH

Explore this scatter interactively →