Kidney epithelium development

Across TCGA patient cohorts, RNA activity of the Kidney epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LARP1, RPL5, and SEPTIN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney epithelium development activity versus LARP1 in OV (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LARP1 →	-0.268	-0.040	.005	.002	3	9
OV	RPL5 →	-0.223	-0.039	<.001	<.001	3	8
OV	SEPTIN4 →	+0.549	+0.038	.003	.001	3	8
PDAC	EFEMP1 →	+0.751	+0.032	<.001	<.001	3	8
UCEC	EIF2S2 →	-0.247	-0.060	<.001	<.001	3	8
BRCA	FEN1 →	-0.449	-0.032	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072073 vs LARP1 — OV

Explore this scatter interactively →